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items: Muscimol as an Ionotropic GABA Receptor Agonist
items: Amanita muscaria: Basic Info
items: Amanita Mushroom Effects
items: Amanita Muscaria vs. Psychedelic Mushrooms (Psilocybin): What’s the Difference?

Muscimol as an Ionotropic GABA Receptor Agonist
type: item
creator: admin
date: 2023-11-13T12:15:28Z
subject: main
description: Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe […] The post Muscimol as an Ionotropic GABA Receptor Agonist first appeared on apoembiotech.
encoded: Muscimol, a psychoactive isoxazole from Amanita muscaria and related mushrooms, has proved to be a remarkably selective agonist at ionotropic receptors for the inhibitory neurotransmitter GABA. This historic overview highlights the discovery and development of muscimol and related compounds as a GABA agonist by Danish and Australian neurochemists. Muscimol is widely used as a ligand to probe GABA receptors and was the lead compound in the development of a range of GABAergic agents including nipecotic acid, tiagabine, 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, (Gaboxadol®) and 4-PIOL. References Wieland T (1968) Poisonous principles of mushrooms of the genus Amanita. Science 159:946–952 Article PubMed CAS Google Scholar Wasson RG (1968) Soma: Divine Mushroom of Immortality. Harcourt Brace Jovanovich, New York Google Scholar DeFeudis FV (1980) Physiological and behavioral studies with muscimol. Neurochem Res 5:1047–1068 Article PubMed CAS Google Scholar Eugster CH, Takemoto T (1967) Zür Nomenclature der neuen Verbindungen aus Amanita-Arten. Helv Chim Acta 50:126–127 Article PubMed CAS <a href="http://scholar.google.com/scholar_lookup?&title=Z%C3%BCr%20Nomenclature%20der%20neuen%20Verbindungen%20aus%20Amanita-Arten&journal=Helv%20Chim%20Acta&doi=10.1002%2Fhlca.19670500119&volume=50&pages=126-127&publication_year=1967&author=Eugster%2CCH&author=Takemoto%2CT" rel="nofollow noopener" data-track="click" data-track-action="google scholar reference" data-track-label="link" aria-label="Google Scholar reference 4">Google Scholar Johnston GAR, Curtis DR, De Groat WC, Duggan AW (1968) Central actions of ibotenic acid and muscimol. Biochem Pharmacol 17:2488–2489 Article PubMed CAS <a href="http://scholar.google.com/scholar_lookup?&title=Central%20actions%20of%20ibotenic%20acid%20and%20muscimol&journal=Biochem%20Pharmacol&doi=10.1016%2F0006-2952%2868%2990141-X&volume=17&pages=2488-2489&publication_year=1968&author=Johnston%2CGAR&author=Curtis%2CDR&author=Groat%2CWC&author=Dug…

Amanita muscaria: Basic Info
type: item
creator: admin
date: 2023-11-13T12:15:19Z
subject: main
description: Amanita muscaria (and another similar variety, Amanita pantherina) is a mushroom of the agaricales order that appears in very broad habitats of the temperate and boreal zones of the Northern Hemisphere. It grows both in low altitudes and high mountainous areas, especially in coniferous forests such as fir and black pine, as well as in beech and […] The post Amanita muscaria: Basic Info first appeared on apoembiotech.
encoded: Amanita muscaria (and another similar variety, Amanita pantherina) is a mushroom of the agaricales order that appears in very broad habitats of the temperate and boreal zones of the Northern Hemisphere. It grows both in low altitudes and high mountainous areas, especially in coniferous forests such as fir and black pine, as well as in beech and birch forests. It usually appears during the end of summer months and is especially prevalent in autumn. Its appearance is well known by the red color of the cap, covered with white dots, as well as the white stem. This mushroom contains two psychoactive alkaloids, ibotenic acid and muscimol, in addition to many other alkaloids. It has been used since antiquity as an intoxicating substance as well as in shamanic contexts and divination. The name Amanita muscaria comes from the paralyzing effect it has on some insects. It is known by other names such as hongo matamoscas in Spanish, falsa oronja, reig bord or farinera borda in Catalan, and fly agaric in English. Origin/History Historical records such as cave paintings, wood carvings and sculptures suggest that the psychoactive effects of A. muscaria have been known since ancient times on all continents, and similar practices have been observed regarding the use of A. muscaria in groups both geographically and culturally distant. A. muscaria has been used for religious, divination, therapeutic and social purposes. The first evidence of the use of A. muscaria as an intoxicant is based on linguistic analyses of North Asian languages from 4000 BCE, in which the roots of the words “drunkenness” and Amanita muscaria appear to be the same. Polychromatic paintings have been found on Saharan rocks dating back to the Paleolithic period; depictions of what appear to be mushrooms of the Amanita genus, probably of the muscaria species. The fungus grows naturally in the highlands of Mesoamerica and some mushroom myths and sculptures suggest the use of A. muscaria in Guatemala and southern Me…

Amanita Mushroom Effects
type: item
creator: admin
date: 2023-11-13T12:15:12Z
subject: main
description: Magic Mushrooms Are you curious about the mystical world of mushrooms and their mind-altering abilities? Many people are fascinated by the legendary Amanita muscaria, commonly known as the fly agaric mushroom. Its striking red cap with white spots has made it a staple in fairy tales and folklore, but beyond its enchanting appearance lies […] The post Amanita Mushroom Effects first appeared on apoembiotech.
encoded: Magic Mushrooms Are you curious about the mystical world of mushrooms and their mind-altering abilities? Many people are fascinated by the legendary Amanita muscaria, commonly known as the fly agaric mushroom. Its striking red cap with white spots has made it a staple in fairy tales and folklore, but beyond its enchanting appearance lies a complex blend of chemicals that can significantly impact human consciousness. One intriguing fact is that fly agaric mushrooms contain psychoactive substances like muscimol and ibotenic acid which interact with our brain to produce an array of effects ranging from mild euphoria to powerful hallucinations. As you delve into this blog post, we will unpack the many facets of Amanita muscaria’s influence on our minds and bodies. We’ll explore historical uses, cultural significance, scientific research, legal status, and safe practices so you can be well-informed about these potent fungi. Ready for a journey through the enigmatic realm of Amanitas? Let’s discover what makes these mushrooms truly spellbinding! Key Takeaways Amanita muscaria, also known as fly agaric mushrooms, contain psychoactive substances like muscimol and ibotenic acid which can alter human consciousness. Consuming these mushrooms can lead to effects ranging from mild euphoria to intense hallucinations, but dosage and individual sensitivity greatly impact the experience. While some cultures have used Amanita mushrooms for their psychoactive properties in rituals and spiritual practices, they are toxic and can cause severe health risks if misused. Legal status of Amanita muscaria varies by country; in some places they are not regulated while in others they may be considered a controlled substance due to their psychoactive compounds. Ongoing research is investigating the medicinal potential of Amanitas including their use in modern psychotherapy for conditions such as depression and anxiety. Psychoactive Compounds: Muscimol and Ibotenic Acid Muscimol and ibotenic acid…

Amanita Muscaria vs. Psychedelic Mushrooms (Psilocybin): What’s the Difference?
type: item
creator: admin
date: 2023-11-13T12:14:21Z
subject: main
description: Amanita muscaria, or fly agaric, is the iconic red-and-white-speckled mushroom that is embodied everywhere, from garden statues to emojis. Fly agaric mushrooms are certainly psychoactive, but they differ from traditional magic mushrooms. The phrase “magic mushroom” typically refers to far less colorful psilocybin-containing varieties that can elicit transcendent, mind-manifesting states. What sets Amanita muscaria apart […] The post Amanita Muscaria vs. Psychedelic Mushrooms (Psilocybin): What’s the Difference? first appeared on apoembiotech.
encoded: Amanita muscaria, or fly agaric, is the iconic red-and-white-speckled mushroom that is embodied everywhere, from garden statues to emojis. Fly agaric mushrooms are certainly psychoactive, but they differ from traditional magic mushrooms. The phrase “magic mushroom” typically refers to far less colorful psilocybin-containing varieties that can elicit transcendent, mind-manifesting states. What sets Amanita muscaria apart from traditional magic (psilocybin) mushroom varieties transcends appearances and effects. Here we explore the main differences between Amanita muscaria and psychedelic mushrooms, examining where they grow, active ingredients, medicinal value, lab testing, and legality. An overview of Amanita muscaria and psilocybin mushrooms Mushrooms containing psilocybin, more commonly known as “magic mushrooms” or “shrooms,” are fungi that contain the psychoactive compound psilocybin, a naturally occurring psychedelic agent, which, when ingested, turns into psilocin and is known to produce powerful visualizations and mystical experiences. At a glance: Psychedelic (Psilocybin) mushrooms usually have light tan to off-white caps of varying sizes and white to brown stems, sometimes with a bluish tinge. More than 200 species of mushrooms contain psilocybin or its derivative, psilocin. Psilocybe cubensis is a species that is commonly studied; and within this the subspecies «Golden Teachers» are very loved for their gentle, guiding messages. Psilocybin mushrooms are among the most popular and commonly used magic mushrooms in the U.S. and Europe, with a long history in spiritual and religious rituals. Amanita muscaria mushrooms are also known as “fly agaric” due to their ability to attract and kill flies. This psychoactive species contains muscimol, ibotenic acid, and muscarine as the main active compounds. Amanita mushrooms can be toxic when consumed raw and are related to several deadly varieties, including Amanita phalloides (known as the “Death Cap”). At a glance: A.…